Identification of novel biomarkers for arthrofibrosis after total knee arthroplasty in animal models and clinical patients.

ABSTRACT:

Background

Arthrofibrosis is a debilitating complication after total knee arthroplasty (TKA) which becomes a considerable burden for both patients and clinical practitioners. Our study aimed to identify novel biomarkers and therapeutic targets for drug discovery.

Methods

Potential biomarker genes were identified based on bioinformatic analysis. Twelve male New Zealand white rabbits underwent surgical fixation of unilateral knees to mimics the joint immobilization of the clinical scenario after TKA surgery. Macroscopic assessment, hydroxyproline content determination, and histological analysis of tissue were performed separately after 3-days, 1-week, 2-weeks, and 4-weeks of fixation. We also enrolled 46 arthrofibrosis patients and 92 controls to test the biomarkers. Clinical

SUBMITTER: Chen X 

PROVIDER: S-EPMC8325099 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature