The Association of Aging-Related Polymorphisms with Susceptibility to Lung Cancer: A Case-Control Study in a Japanese Population.

ABSTRACT:

Background

Telomere length is associated with cancer as well as aging.  Telomerase reverse transcriptase (TERT), telomere RNA component (TERC) and oligonucleotide/oligosaccharide-binding fold containing 1 (OBFC1) are known to be involved in telomere length regulation. The tumor suppressor p53 (TP53), which has been shown to interact with tumor protein p53-binding protein 1 (TP53BP1), is implicated in the response to telomere shortening and aging.  Polymorphisms in the TP53 and TP53BP1 genes are associated with various types of cancer. The aim of this study is to evaluate the impact of aging-related polymorphisms on lung cancer risk.

Materials and methods

This case-control study consists of 462 lung cancer cases and 379 controls from Japan.  We examined the effect of TERT rs2

SUBMITTER: Furuie H 

PROVIDER: S-EPMC8325147 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature