Predicting in vivo escape dynamics of HIV-1 from a broadly neutralizing antibody.

ABSTRACT: Broadly neutralizing antibodies are promising candidates for treatment and prevention of HIV-1 infections. Such antibodies can temporarily suppress viral load in infected individuals; however, the virus often rebounds by escape mutants that have evolved resistance. In this paper, we map a fitness model of HIV-1 interacting with broadly neutralizing antibodies using in vivo data from a recent clinical trial. We identify two fitness factors, antibody dosage and viral load, that determine viral reproduction rates reproducibly across different hosts. The model successfully predicts the escape dynamics of HIV-1 in the course of an antibody treatment, including a characteristic frequency turnover between sensitive and resistant strains. This turnover is governed by a dosage-dependent fitness ran

SUBMITTER: Meijers M 

PROVIDER: S-EPMC8325275 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature