HumGut: a comprehensive human gut prokaryotic genomes collection filtered by metagenome data.

ABSTRACT:

Background

A major bottleneck in the use of metagenome sequencing for human gut microbiome studies has been the lack of a comprehensive genome collection to be used as a reference database. Several recent efforts have been made to re-construct genomes from human gut metagenome data, resulting in a huge increase in the number of relevant genomes. In this work, we aimed to create a collection of the most prevalent healthy human gut prokaryotic genomes, to be used as a reference database, including both MAGs from the human gut and ordinary RefSeq genomes.

Results

We screened > 5,700 healthy human gut metagenomes for the containment of > 490,000 publicly available prokaryotic genomes sourced from RefSeq and the recently announced UHGG collection. This resulted in a pool of > 381

SUBMITTER: Hiseni P 

PROVIDER: S-EPMC8325300 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature