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Biomaterial-Facilitated Immunotherapy for Established Oral Cancers.

ABSTRACT: We evaluated a peptide-based immunotherapy termed SynerGel: an injectable, biomaterial-based platform for intratumoral drug delivery. A drug-mimicking peptide hydrogel named L-NIL-MDP was loaded with an antitumor cyclic dinucleotide (CDN) immunotherapy agonist. The biomaterial combines inducible nitric oxide synthase (iNOS) inhibition with controlled delivery of CDNs, demonstrating between 4- and 20-fold slower drug release than commercially available hydrogels. SynerGel allowed for immune-mediated elimination of established treatment-resistant oral tumors in a murine model, with a median survival of 67.5 days compared with 44 days in no-treatment control. This report details findings for a promising therapy showing improved efficacy over previous hydrogel systems.

SUBMITTER: Leach DG

PROVIDER: S-EPMC8325389 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Biomaterial-Facilitated Immunotherapy for Established Oral Cancers.

Leach David G DG Dharmaraj Neeraja N Lopez-Silva Tania L TL Venzor Jose Rodriguez JR Pogostin Brett H BH Sikora Andrew G AG Hartgerink Jeffrey D JD Young Simon S

ACS biomaterials science & engineering 20210120 2

We evaluated a peptide-based immunotherapy termed SynerGel: an injectable, biomaterial-based platform for intratumoral drug delivery. A drug-mimicking peptide hydrogel named L-NIL-MDP was loaded with an antitumor cyclic dinucleotide (CDN) immunotherapy agonist. The biomaterial combines inducible nitric oxide synthase (iNOS) inhibition with controlled delivery of CDNs, demonstrating between 4- and 20-fold slower drug release than commercially available hydrogels. SynerGel allowed for immune-media ...[more]

PMID: 33470801

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