Comparative Analysis of the Extracellular Matrix Proteome across the Myotendinous Junction.

ABSTRACT: The myotendinous junction is a highly interdigitated interface designed to transfer muscle-generated force to tendon. Understanding how this interface is formed and organized, as well as identifying tendon- and muscle-specific extracellular matrix (ECM), is critical for designing effective regenerative therapies to restore functionality to damaged muscle-tendon units. However, a comparative analysis of the ECM proteome across this interface has not been conducted. The goal of this study was to resolve the distribution of ECM proteins that are uniformly expressed as well as those specific to each of the muscle, tendon, and junction tissues. The soleus muscles from 5-month-old wild-type C57BL/6 mice were harvested and dissected into the central muscle (M) away from tendon, the junction betwe

SUBMITTER: Jacobson KR 

PROVIDER: S-EPMC8325396 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature