Efficacy and safety of remdesivir in hospitalised COVID-19 patients: a systematic review and meta-analysis.

ABSTRACT:

Purpose

This review was aimed to synthesise the best available evidence on the effectiveness and safety of remdesivir in the treatment of moderate to severe COVID-19.

Method

Randomised controlled trials (RCTs) and observational studies reporting the effectiveness and safety of remdesivir were searched via databases and other sources from December 2019 to December 2020. Two independent reviewers performed literature screening, data extraction and assessment of risk bias. Seven studies involving 3686 patients were included.

Results

Treatment with remdesivir was associated with an increase in clinical recovery rate by 21% (RR 1.21; 95% CI 1.08-1.35) on day 7 and 29% (RR 1.29; 95% CI 1.22-1.37) on day 14. The likelihoods of requiring high-flow supplemental oxygen and inva

SUBMITTER: Angamo MT 

PROVIDER: S-EPMC8325414 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature