A Potential miRNA-mRNA Network for Dementia and Hernia Crosstalk.

ABSTRACT:

Background

It has been reported that there may be a potential link between hernia and dementia. However, the exact mechanisms of their association have not been established. This study is aimed at constructing miRNA-mRNA networks to elucidate on the potential link between dementia and hernia.

Methods

Gene expression profiles for dementia, herniation, and skeletal muscle were downloaded from the GEO database after which differentially expressed mRNAs and miRNAs were obtained. In addition, fascia tissue samples were obtained during surgery. A total of 41 patients were recruited in this study, and expression levels of candidate genes were examined using quantitative RT-PCR. Luciferase reporter gene assays were used to identify potential miRNA-mRNA regulatory pathways.

Result

SUBMITTER: Chen DJ 

PROVIDER: S-EPMC8325595 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature