Optimizing Decellularization Strategies for the Efficient Production of Whole Rat Kidney Scaffolds.

ABSTRACT:

Background

Renal dysfunction remains a global issue, with chronic kidney disease being the 18th most leading cause of death, worldwide. The increased demands in kidney transplants, led the scientific society to seek alternative strategies, utilizing mostly the tissue engineering approaches. Unlike to perfusion decellularization of kidneys, we proposed alternative decellularization strategies to obtain acellular kidney scaffolds. The aim of this study was the evaluation of two different decellularization approaches for producing kidney bioscaffolds.

Methods

Rat kidneys from Wistar rats, were submitted to decellularization, followed two different strategies. The decellularization solutions used in both approaches were the same and involved the use of 3-[(3-cholamidopropyl) dim

SUBMITTER: Mallis P 

PROVIDER: S-EPMC8325734 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature