Directional homing of glycosylation-modified bone marrow mesenchymal stem cells for bone defect repair.

ABSTRACT:

Background

One of the greatest challenges for tissue-engineered bone is the low survival rate of locally grafted cells. The cell homing technology can effectively increase the number of these grafted cells, therefore, enhancing the repair of bone defects. Here we explore the effect of fucosylation modification on the directional homing of bone marrow mesenchymal stem cells (BMSCs) and their ability to repair bone defects.

Results

Glycosylated BMSCs expressed high levels of the Sialyl Lewis-X (sLe^X) antigen, which enabled the cells to efficiently bind to E- and P-selectins and to home to bone defect sites in vivo. Micro-CT and histological staining results confirmed that mice injected with FuT7-BMSCs showed an improved repair of bone defects compared to unmodified

SUBMITTER: Chen L 

PROVIDER: S-EPMC8325817 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature