The dorsal blastopore lip is a source of signals inducing planar cell polarity in the Xenopus neural plate.

ABSTRACT: Coordinated polarization of cells in the tissue plane, known as planar cell polarity (PCP), is associated with a signaling pathway critical for the control of morphogenetic processes. Although the segregation of PCP components to opposite cell borders is believed to play a critical role in this pathway, whether PCP derives from egg polarity or preexistent long-range gradient, or forms in response to a localized cue, remains a challenging question. Here we investigate the Xenopus neural plate, a tissue that has been previously shown to exhibit PCP. By imaging Vangl2 and Prickle3, we show that PCP is progressively acquired in the neural plate and requires a signal from the posterior region of the embryo. Tissue transplantations indicated that PCP is triggered in the neural plate by a planar

SUBMITTER: Mancini P 

PROVIDER: S-EPMC8325942 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature