Human milk 3'-Sialyllactose is positively associated with language development during infancy.

ABSTRACT:

Background

Genetic polymorphisms leading to variations in human milk oligosaccharide (HMO) composition have been reported. Alpha-Tetrasaccharide (A-tetra), an HMO, has been shown to only be present (>limit of detection; A-tetra+) in the human milk (HM) of women with blood type A, suggesting genetic origins determining the presence or absence (A-tetra-) of A-tetra in HM.

Objectives

This study aimed to determine whether associations exist between HMO concentrations and cognitive development, and whether the associations vary between A-tetra+ and A-tetra- groups in children (<25 months old).

Methods

We enrolled typically developing children (2-25 months old; mean, 10 months old) who were at least partially breastfed at the study visit. The Mullen Scales of Early Learning

SUBMITTER: Cho S 

PROVIDER: S-EPMC8326052 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature