Sulfamethoxazole-Altered Transcriptomein Green Alga Raphidocelis subcapitata Suggests Inhibition of Translation and DNA Damage Repair.

ABSTRACT: Occurrence of sulfonamide antibiotics has been reported in surface waters with the exposures ranging from < 1 ng L^-1 to approximately 11 μg L^-1, which may exert adverse effects on non-target algal species, inhibiting algal growth and further hindering the delivery of several ecosystem services. Yet the molecular mechanisms of sulfonamide in algae remain undetermined. The aims of the present work are: (1) to test the hypothesis whether sulfamethoxazole (SMX) inhibits the folate biosynthesis in a model green alga Raphidocelis subcapitata; and (2) to explore the effects of SMX at an environmentally relevant concentration on algal health. Here, transcriptomic analysis was applied to investigate the changes at the molecular levels in R. subcapitata treated wi

SUBMITTER: Guo J 

PROVIDER: S-EPMC8326373 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature