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Biodegradation of Deoxynivalenol by Nocardioides sp. ZHH-013: 3-keto-Deoxynivalenol and 3-epi-Deoxynivalenol as Intermediate Products.


ABSTRACT: Deoxynivalenol (DON) is one of the most devastating and notorious contaminants in food and animal feed worldwide. A novel DON-degrading strain, Nocardioides sp. ZHH-013, which exhibited complete mineralization of DON, was isolated from soil samples. The intermediate products of DON generated by this strain were identified by high-performance liquid chromatography and ultra-performance liquid chromatography tandem mass spectrometry analyses. It was shown that, on an experimental level, 3-keto-DON was a necessary intermediate product during the conversion from DON to 3-epi-DON. Furthermore, the ZHH-013 strain could also utilize 3-epi-DON. This DON degradation pathway is a safety concern for food and feed. The mechanism of DON and 3-epi-DON elimination will be further studied, so that new enzymes for DON degradation can be identified.

SUBMITTER: Zhang H 

PROVIDER: S-EPMC8326517 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Biodegradation of Deoxynivalenol by <i>Nocardioides</i> sp. ZHH-013: 3-<i>keto</i>-Deoxynivalenol and 3-<i>epi</i>-Deoxynivalenol as Intermediate Products.

Zhang Honghai H   Zhang Heng H   Qin Xing X   Wang Xiaolu X   Wang Yuan Y   Bin Yao Y   Xie Xiangming X   Zheng Fei F   Luo Huiying H  

Frontiers in microbiology 20210719


Deoxynivalenol (DON) is one of the most devastating and notorious contaminants in food and animal feed worldwide. A novel DON-degrading strain, <i>Nocardioides</i> sp. ZHH-013, which exhibited complete mineralization of DON, was isolated from soil samples. The intermediate products of DON generated by this strain were identified by high-performance liquid chromatography and ultra-performance liquid chromatography tandem mass spectrometry analyses. It was shown that, on an experimental level, 3-<  ...[more]

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