Proadrenomedullin Predicts Severe Disease in Children With Suspected Community-acquired Pneumonia.

ABSTRACT:

Background

Proadrenomedullin (proADM), a vasodilatory peptide with antimicrobial and anti-inflammatory properties, predicts severe outcomes in adults with community-acquired pneumonia (CAP) to a greater degree than C-reactive protein and procalcitonin. We evaluated the ability of proADM to predict disease severity across a range of clinical outcomes in children with suspected CAP.

Methods

We performed a prospective cohort study of children 3 months to 18 years with CAP in the emergency department. Disease severity was defined as mild (discharged home), mild-moderate (hospitalized but not moderate-severe or severe), moderate-severe (eg, hospitalized with supplemental oxygen, broadening of antibiotics, complicated pneumonia), and severe (eg, vasoactive infusions, chest drainag

SUBMITTER: Florin TA 

PROVIDER: S-EPMC8326530 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature