Linking Inflammatory Bowel Disease Symptoms to Changes in the Gut Microbiome Structure and Function.

ABSTRACT: Inflammatory bowel disease (IBD) is a chronic disease of the gastrointestinal tract that is often characterized by abdominal pain, rectal bleeding, inflammation, and weight loss. Many studies have posited that the gut microbiome may play an integral role in the onset and exacerbation of IBD. Here, we present a novel computational analysis of a previously published IBD dataset. This dataset consists of shotgun sequence data generated from fecal samples collected from individuals with IBD and an internal control group. Utilizing multiple external controls, together with appropriate techniques to handle the compositionality aspect of sequence data, our computational framework can identify and corroborate differences in the taxonomic profiles, bacterial association networks, and functional cap

SUBMITTER: Hassouneh SA 

PROVIDER: S-EPMC8326577 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature