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Increased circulating levels of angiotensin-(1-7) in severely ill COVID-19 patients.

ABSTRACT: This letter reports an unexpected increase of the ACE2 product angiotensin-(1-7) and a parallel decrease of its substrate angiotensin II, suggesting a dysregulation of the renin-angiotensin system towards angiotensin-(1-7) formation in #COVID19 patients https://bit.ly/3xFXuTU.

SUBMITTER: Valle Martins AL

PROVIDER: S-EPMC8326714 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Increased circulating levels of angiotensin-(1-7) in severely ill COVID-19 patients.

Valle Martins Ana Luiza AL da Silva Filipe Alex FA Bolais-Ramos Lucas L de Oliveira Gisele Capanema GC Ribeiro Renata Cunha RC Pereira Danilo Augusto Alves DAA Annoni Filippo F Diniz Mirella Monique Lana MML Silva Thuanny Granato Fonseca TGF Zivianni Bruna B Cardoso Alexandre Carvalho AC Martins Juliana Carvalho JC Motta-Santos Daisy D Campagnole-Santos Maria José MJ Taccone Fabio Silvio FS Verano-Braga Thiago T Santos Robson Augusto Souza RAS

ERJ open research 20210701 3

<b>This letter reports an unexpected increase of the ACE2 product angiotensin-(1-7) and a parallel decrease of its substrate angiotensin II, suggesting a dysregulation of the renin-angiotensin system towards angiotensin-(1-7) formation in #COVID19 patients</b> https://bit.ly/3xFXuTU. ...[more]

PMID: 34350288

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