Differentially Expressed Gene Pathways in the Conjunctiva of Sjogren Syndrome Keratoconjunctivitis Sicca.

ABSTRACT: Sjögren syndrome (SS) is an autoimmune condition that targets the salivary and lacrimal glands, with cardinal clinical signs of dry eye (keratoconjunctivitis sicca, KCS) and dry mouth. The conjunctiva of SS patients is often infiltrated by immune cells that participate in the induction and maintenance of local inflammation. The purpose of this study was to investigate immune-related molecular pathways activated in the conjunctiva of SS patients. Female SS patients (n=7) and controls (n=19) completed a series of oral, ocular surface exams. Symptom severity scores were evaluated using validated questionnaires (OSDI and SANDE). All patients fulfilled the ACR/EULAR criteria for SS and the criteria for KCS. Fluorescein and lissamine green dye staining evaluated tear-break-up time (TBUT), cornea

SUBMITTER: de Paiva CS 

PROVIDER: S-EPMC8326832 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature