Stratification of Systemic Lupus Erythematosus Patients Into Three Groups of Disease Activity Progression According to Longitudinal Gene Expression.

ABSTRACT:

Objective

The highly heterogeneous clinical presentation of systemic lupus erythematosus (SLE) is characterized by the unpredictable occurrence of disease flares and organ damage. Attempts to stratify lupus patients have been limited to classification based on clinical information, leading to unsuccessful clinical trials and controversial research results. This study was undertaken to develop and validate a robust method to stratify patients with lupus according to longitudinal disease activity and whole-genome gene expression data in order to establish subgroups of patients who share disease progression mechanisms.

Methods

We used a cluster-based approach to stratify SLE patients based on the correlation between disease activity scores and longitudinal gene expression infor

SUBMITTER: Toro-Dominguez D 

PROVIDER: S-EPMC8326877 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature