Effects of Donor-Recipient Age Difference in Renal Transplantation, an Investigation on Renal Function and Fluid Proteome.

ABSTRACT:

Introduction

Our previous study revealed that a young internal environment ameliorated kidney aging by virtue of an animal model of heterochronic parabiosis and a model of heterochronic renal transplantation. In this research, we used proteome to investigate the effects of donor-recipient age difference in clinical renal transplantation.

Methods

This study included 10 pairs of renal transplantation donors and recipients with an age difference of greater than 20 years to their corresponding recipients/donors. All recipients have received transplantation more than 3 years ago. Renal function and the serum/urine proteomes of the donors and recipients were analyzed.

Results

The renal function was similar between the young recipients and the old donors. In contrast, the re

SUBMITTER: Wang X 

PROVIDER: S-EPMC8326938 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature