Altered Fecal Metabolites and Colonic Glycerophospholipids Were Associated With Abnormal Composition of Gut Microbiota in a Depression Model of Mice.

ABSTRACT: The microbiota-gut-brain axis has been considered to play an important role in the development of depression, but the underlying mechanism remains unclear. The gastrointestinal tract is home to trillions of microbiota and the colon is considered an important site for the interaction between microbiota and host, but few studies have been conducted to evaluate the alterations in the colon. Accordingly, in this study, we established a chronic social defeated stress (CSDS) mice model of depression. We applied 16S rRNA gene sequencing to assess the gut microbial composition and gas and liquid chromatography-mass spectroscopy to identify fecal metabolites and colonic lipids, respectively. Meanwhile, we used Spearman's correlation analysis method to evaluate the associations between the gut micro

SUBMITTER: Gong X 

PROVIDER: S-EPMC8326978 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature