Regional and depth-dependence of cortical blood-flow assessed with high-resolution Arterial Spin Labeling (ASL).

ABSTRACT: Methods for imaging of cerebral blood flow do not typically resolve the cortex and thus underestimate flow. However, recent work with high-resolution MRI has emphasized the regional and depth-dependent structural, functional and relaxation times variations within the cortex. Using high-resolution Arterial Spin Labeling (ASL) and T₁ mapping acquisitions, we sought to probe the effects of spatial resolution and tissue heterogeneity on cortical cerebral blood flow (CBF) measurements with ASL. We acquired high-resolution (1.6mm)³ whole brain ASL data in a cohort of 10 volunteers at 3T, along with T₁ and transit-time (ATT) mapping, followed by group cortical surface-based analysis using FreeSurfer of the different measured parameters. Fully resolved regional ana

SUBMITTER: Taso M 

PROVIDER: S-EPMC8327107 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature