Role of endothelium-pericyte signaling in capillary blood flow response to neuronal activity.

ABSTRACT: Local blood flow in the brain is tightly coupled to metabolic demands, a phenomenon termed functional hyperemia. Both capillaries and arterioles contribute to the hyperemic response to neuronal activity via different mechanisms and timescales. The nature and specific signaling involved in the hyperemic response of capillaries versus arterioles, and their temporal relationship are not fully defined. We determined the time-dependent changes in capillary flux and diameter versus arteriolar velocity and flow following whisker stimulation using optical microangiography (OMAG) and two-photon microscopy. We further characterized depth-resolved responses of individual capillaries versus capillary networks. We hypothesized that capillaries respond first to neuronal activation, and that they exhibit

SUBMITTER: Zhang W 

PROVIDER: S-EPMC8327110 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature