AeMOPE-1, a Novel Salivary Peptide From <i>Aedes aegypti</i>, Selectively Modulates Activation of Murine Macrophages and Ameliorates Experimental Colitis.

ABSTRACT: The sialotranscriptomes of Aedes aegypti revealed a transcript overexpressed in female salivary glands that codes a mature 7.8 kDa peptide. The peptide, specific to the Aedes genus, has a unique sequence, presents a putative secretory nature and its function is unknown. Here, we confirmed that the peptide is highly expressed in the salivary glands of female mosquitoes when compared to the salivary glands of males, and its secretion in mosquito saliva is able to sensitize the vertebrate host by inducing the production of specific antibodies. The synthetic version of the peptide downmodulated nitric oxide production by activated peritoneal murine macrophages. The fractionation of a Ae. aegypti salivary preparation revealed that the fractions containing the naturally secr

SUBMITTER: Lara PG 

PROVIDER: S-EPMC8327214 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature