Regional amyloid accumulation predicts memory decline in initially cognitively unimpaired individuals.

ABSTRACT:

Introduction

The value of quantitative longitudinal and regional amyloid beta (Aβ) measurements in predicting cognitive decline in initially cognitively unimpaired (CU) individuals remains to be determined.

Methods

We selected 133 CU individuals with two or more [¹¹C]Pittsburgh compound B ([¹¹C]PiB) scans and neuropsychological data from Open Access Series of Imaging Studies (OASIS-3). Baseline and annualized distribution volume ratios were computed for a global composite and four regional clusters. The predictive value of Aβ measurements (baseline, slope, and interaction) on longitudinal cognitive performance was examined.

Results

Global performance could only be predicted by Aβ burden in an early cluster (precuneus, lateral orbitofrontal, and i

SUBMITTER: Collij LE 

PROVIDER: S-EPMC8327468 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature