Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes.

ABSTRACT:

Background

Obesity predisposes individuals to multiple cardiometabolic disorders, including type 2 diabetes (T2D). As body mass index (BMI) cannot reliably differentiate fat from lean mass, the metabolically detrimental abdominal obesity has been estimated using waist-hip ratio (WHR). Waist-hip ratio adjusted for body mass index (WHRadjBMI) in turn is a well-established sex-specific marker for abdominal fat and adiposity, and a predictor of adverse metabolic outcomes, such as T2D. However, the underlying genes and regulatory mechanisms orchestrating the sex differences in obesity and body fat distribution in humans are not well understood.

Methods

We searched for genetic master regulators of WHRadjBMI by employing integrative genomics approaches on human subcutaneous adipose

SUBMITTER: Pan DZ 

PROVIDER: S-EPMC8327600 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature