Neoantigen load as a prognostic and predictive marker for stage II/III non-small cell lung cancer in Chinese patients.

ABSTRACT:

Background

The prognosis for patients with stage II/III non-small cell lung cancer (NSCLC) is unsatisfactory, even after complete tumor resection and adjuvant chemotherapy. Here, we assessed the prognostic and predictive value of immunogenomic signatures for stage II/III NSCLC in Chinese patients.

Methods

A total of 91 paired resected stage II/III NSCLC and normal tissues, including 47 squamous cell lung carcinomas (SCC) and 44 lung adenocarcinomas (ADC), were collected and analyzed using whole exome sequencing (WES) to identify immunogenomic signatures for association with clinicopathological variables and disease-free survival (DFS).

Results

Higher neoantigen load (NAL, >2 neoantigens/Mb) exhibited better DFS for SCC patients (p = 0.021) but not ADC patients. A bene

SUBMITTER: Gong L 

PROVIDER: S-EPMC8327700 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature