Genetic predictors to acupuncture response for hot flashes: an exploratory study of breast cancer survivors.

ABSTRACT:

Objective

Because hot flashes are a common symptom experienced by women with breast cancer, we sought to explore genetic predictors associated with response to acupuncture for the treatment of hot flashes.

Methods

Using data from our completed randomized controlled trial (Clinicaltrials.gov identifier: NCT01005108) on hot flashes among breast cancer survivors who provided biomarker collection (N = 108), we extracted and assayed DNA for single nucleotide polymorphisms in genes involved in neurotransmission, thermoregulation, and inflammation (ADORA1, COMT, TCL1A, and TRPV1). For our primary outcome we classified individuals with a 50% or more reduction in their hot flash composite score at the end of treatment as responders. We used Fisher exact test to identify individual an

SUBMITTER: Romero SAD 

PROVIDER: S-EPMC8327755 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature