Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies.

ABSTRACT: With the broad application of cancer immunotherapies such as immune checkpoint inhibitors in multiple cancer types, the immunological landscape in the tumor microenvironment (TME) has become enormously important for determining the optimal cancer treatment. Tumors can be immunologically divided into two categories: inflamed and non-inflamed based on the extent of immune cell infiltration and their activation status. In general, immunotherapies are preferable for the inflamed tumors than for non-inflamed tumors. Regulatory T cells (Tregs), an immunosuppressive subset of CD4+ T cells, play an essential role in maintaining self-tolerance and immunological homeostasis. In tumor immunity, Tregs compromise immune surveillance against cancer in healthy individuals and impair the antitumor immune

SUBMITTER: Nishikawa H 

PROVIDER: S-EPMC8327843 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature