Application of a novel haplotype-based scan for local adaptation to study high-altitude adaptation in rhesus macaques.

ABSTRACT: When natural populations split and migrate to different environments, they may experience different selection pressures that can lead to local adaptation. To capture the genomic patterns of a local selective sweep, we develop XP-nSL, a genomic scan for local adaptation that compares haplotype patterns between two populations. We show that XP-nSL has power to detect ongoing and recently completed hard and soft sweeps, and we then apply this statistic to search for evidence of adaptation to high altitude in rhesus macaques. We analyze the whole genomes of 23 wild rhesus macaques captured at high altitude (mean altitude > 4000 m above sea level) to 22 wild rhesus macaques captured at low altitude (mean altitude < 500 m above sea level) and find evidence of local adaptation in the high-altitud

SUBMITTER: Szpiech ZA 

PROVIDER: S-EPMC8327953 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature