Brain derived neurotrophic factor declines after complete curative resection in gastrointestinal cancer.

ABSTRACT:

Background

Brain derived neurotrophic factor (BDNF) is a neurotrophin involved in neural and metabolic diseases, but it is also one of the crucial factors in cancer development and metastases. In the current study, we investigated serum BDNF concentrations in patients that underwent surgical treatment for colorectal cancer or pancreatic cancer.

Methods

Serum BDNF concentrations were measured with standard enzyme-linked immunosorbent assays, before and on the third day after the operation, in 50 consecutive patients with colorectal cancer and 25 patients with pancreatic cancer (tumours in the head of pancreas). We compared pre- and postoperative BDNF levels, according to the subsequent TNM stage, histologic stage, lymph node involvement, neuro- or angio-invasion, and resectio

SUBMITTER: Guzel T 

PROVIDER: S-EPMC8327966 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature