Blood microbiota and metabolomic signature of major depression before and after antidepressant treatment: a prospective case-control study.

ABSTRACT:

Background

The microbiota interacts with the brain through the gut-brain axis, and a distinct dysbiosis may lead to major depressive episodes. Bacteria can pass through the gut barrier and be found in the blood. Using a multiomic approach, we investigated whether a distinct blood microbiome and metabolome was associated with major depressive episodes, and how it was modulated by treatment.

Methods

In this case-control multiomic study, we analyzed the blood microbiome composition, inferred bacterial functions and metabolomic profile of 56 patients experiencing a current major depressive episode and 56 matched healthy controls, before and after treatment, using 16S rDNA sequencing and liquid chromatography coupled to tandem mass spectrometry.

Results

The baseline blood

SUBMITTER: Ciocan D 

PROVIDER: S-EPMC8327971 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature