H3K27me3 loss indicates an increased risk of recurrence in the Tubingen meningioma cohort.

ABSTRACT:

Background

A loss of the trimethylation of lysine 27 of histone H3 (H3K27me3) in meningioma has been recently suggested as an adjunct to identify subsets of higher risk of recurrence. The aim of the present study was to assess the prognostic value of H3K27 histone trimethylation and its potential clinical utility in the "Tübingen meningioma cohort."

Methods

Patients who underwent meningioma resection between October 2003 and December 2015 at the University Hospital Tübingen were included. Immunohistochemical stainings for H3K27me3 and the proliferation marker MIB1 were assessed and correlated with clinical parameters using univariate and multivariate Cox regressions as well as Pearson's chi-squared and log-rank test.

Results

Overall, 1268 meningiomas were analyzed wit

SUBMITTER: Behling F 

PROVIDER: S-EPMC8328015 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature