Establishing anchor-based minimally important differences for the EORTC QLQ-C30 in glioma patients.

ABSTRACT:

Background

Minimally important differences (MIDs) allow interpretation of the clinical relevance of health-related quality of life (HRQOL) results. This study aimed to estimate MIDs for all European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30) scales for interpreting group-level results in brain tumor patients.

Methods

Clinical and HRQOL data from three glioma trials were used. Clinical anchors were selected for each EORTC QLQ-C30 scale, based on correlation (>0.30) and clinical plausibility of association. Changes in both HRQOL and the anchors were calculated, and for each scale and time period, patients were categorized into one of the three clinical change groups: deteriorated by one anchor category, no change,

SUBMITTER: Dirven L 

PROVIDER: S-EPMC8328025 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature