Loss of H3K27me3 in meningiomas.

ABSTRACT:

Background

There is a critical need for objective and reliable biomarkers of outcome in meningiomas beyond WHO classification. Loss of H3K27me3 has been reported as a prognostically unfavorable alteration in meningiomas. We sought to independently evaluate the reproducibility and prognostic value of H3K27me3 loss by immunohistochemistry (IHC) in a multicenter study.

Methods

IHC staining for H3K27me3 and analyses of whole slides from 181 meningiomas across three centers was performed. Staining was analyzed by dichotomization into loss and retained immunoreactivity, and using a 3-tiered scoring system in 151 cases with clear staining. Associations of grouping with outcome were performed using Kaplan-Meier survival estimates.

Results

A total of 21 of 151 tumors (13.9%) d

SUBMITTER: Nassiri F 

PROVIDER: S-EPMC8328029 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature