Partitioned glioma heritability shows subtype-specific enrichment in immune cells.

ABSTRACT:

Background

Epidemiological studies of adult glioma have identified genetic syndromes and 25 heritable risk loci that modify individual risk for glioma, as well increased risk in association with exposure to ionizing radiation and decreased risk in association with allergies. In this analysis, we assess whether there is a shared genome-wide genetic architecture between glioma and atopic/autoimmune diseases.

Methods

Using summary statistics from a glioma genome-wide association studies (GWAS) meta-analysis, we identified significant enrichment for risk variants associated with gene expression changes in immune cell populations. We also estimated genetic correlations between glioma and autoimmune, atopic, and hematologic traits using linkage disequilibrium score regression (LDS

SUBMITTER: Ostrom QT 

PROVIDER: S-EPMC8328033 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature