Health-related quality of life in patients with systemic sclerosis: evolution over time and main determinants.

ABSTRACT:

Objectives

In SSc patients, disease specific determinants that influence health-related quality of life (HRQoL) over time have not been described. We aim to, in patients with SSc, (i) evaluate if and how HRQoL changes over time, and (ii) assess how different SSc domains and functional impairments contribute to changes in HRQoL over time.

Methods

All SSc patients from the Leiden SSc cohort were included; patients with disease duration <24 months were classified as incident cases. HRQoL was assessed prospectively on an annual basis using the EQ-5D and the SF36. To assess baseline associations between clinical characteristics and HRQoL, linear regressions were performed. To identify possible associations between SSc characteristics and HRQoL change over time, linear mixed model

SUBMITTER: van Leeuwen NM 

PROVIDER: S-EPMC8328503 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature