The impact of different (rheumatoid) arthritis phenotypes on patients' lives.

ABSTRACT:

Objectives

To compare patient-reported outcome (PRO) domains between three arthritis phenotypes [undifferentiated arthritis (UA), autoantibody-negative RA (RA-) and autoantibody-positive RA (RA+)] at diagnosis, after 2 years and over time.

Methods

All UA (n = 130), RA- (n = 176) and RA+ (n = 331) patients from the tREACH trial, a stratified single-blinded trial with a treat-to-target approach, were used. PRO comparisons between phenotypes at baseline and after 2 years were performed with analysis of variance, while a linear mixed model compared them over time. Effect sizes were weighted against the minimal clinically important differences (MCIDs) for each PRO.

Results

RA- patients had a higher disease burden compared with RA+ and UA. At baseline and after 2 years, RA-

SUBMITTER: Luurssen-Masurel N 

PROVIDER: S-EPMC8328508 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature