Transcriptional Patterning of the Ventricular Cardiac Conduction System.

ABSTRACT:

Rationale

The heartbeat is organized by the cardiac conduction system (CCS), a specialized network of cardiomyocytes. Patterning of the CCS into atrial node versus ventricular conduction system (VCS) components with distinct physiology is essential for the normal heartbeat. Distinct node versus VCS physiology has been recognized for more than a century, but the molecular basis of this regional patterning is not well understood.

Objective

To study the genetic and genomic mechanisms underlying node versus VCS distinction and investigate rhythm consequences of failed VCS patterning.

Methods and results

Using mouse genetics, we found that the balance between T-box transcriptional activator, Tbx5, and T-box transcriptional repressor, Tbx3, determined the mole

SUBMITTER: Burnicka-Turek O 

PROVIDER: S-EPMC8328577 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature