Phagocytosis Assay for α-Synuclein Fibril Uptake by Mouse Primary Microglia.

ABSTRACT: Microglia are professional phagocytes in the brain and deficiency in their phagocytic activity plays an important role in Parkinson's disease. This protocol mainly describes the phagocytosis assay for uptake of α-synuclein preformed fibrils, a pathologic form of α-synuclein, by primary microglia.

SUBMITTER: Du C 

PROVIDER: S-EPMC8328642 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature