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Prospects for Epigenetic Targeted Therapies of Bone and Soft-Tissue Sarcomas.

ABSTRACT: Targeted therapies have revolutionized cancer treatment. It is well established that alterations of chromatin configuration and modifications affect tumorigenesis of some, possibly most, bone and soft-tissue sarcomas. As epigenetic regulators play a major role in the development of bone and soft-tissue sarcomas, epigenetic drugs provide a novel potential avenue for rational targeted therapies for these aggressive cancers. The present review summarizes the application of epigenetic drugs for clinical utilization in bone and soft-tissue sarcomas and provides an overview of clinical trials currently evaluating epigenetic therapies in this space.

SUBMITTER: Wang J

PROVIDER: S-EPMC8328687 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Prospects for Epigenetic Targeted Therapies of Bone and Soft-Tissue Sarcomas.

Wang Jun J Elkrief Arielle A Guo Wei W Shukla Neerav N Gounder Mrinal M Ladanyi Marc M

Sarcoma 20210726

Targeted therapies have revolutionized cancer treatment. It is well established that alterations of chromatin configuration and modifications affect tumorigenesis of some, possibly most, bone and soft-tissue sarcomas. As epigenetic regulators play a major role in the development of bone and soft-tissue sarcomas, epigenetic drugs provide a novel potential avenue for rational targeted therapies for these aggressive cancers. The present review summarizes the application of epigenetic drugs for clin ...[more]

PMID: 34349608

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