Identifying Sequence Variants of 18 Hereditary Ovarian Cancer-Associated Genes in Chinese Epithelial Ovarian Cancer Patients.

ABSTRACT:

Objectives

The causes of ovarian cancer (OC) have been confirmed to be closely related to genetic factors. Identifying sequence variants of hereditary ovarian cancer (HOC) susceptibility genes can increase clinical surveillance, facilitate early detection, and provide personalized treatment for patients. This study is aimed at investigating the variation frequency of HOC susceptibility genes in the Chinese population and providing information for the etiology and genetics of OC.

Methods

118 epithelial OC patients were recruited in this clinical study. Variants of 18-gene panel were detected in blood samples by next-generation sequencing (NGS) technology.

Results

Overall, 36.44% (43/118) of patients carried at least one pathogenic variant. Among these, BRCA1 pat

SUBMITTER: Wu X 

PROVIDER: S-EPMC8328723 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature