The Secretome Deregulations in a Rat Model of Endotoxemic Shock.

ABSTRACT:

Introduction

Septic shock is a systemic inflammatory response syndrome associated with organ failures. Earlier clinical diagnosis would be of benefit to a decrease in the mortality rate. However, there is currently a lack of predictive biomarkers. The secretome is the set of proteins secreted by a cell, tissue, or organism at a given time and under certain conditions. The plasma secretome is easily accessible from biological fluids and represents a good opportunity to discover new biomarkers that can be studied with nontargeted "omic" strategies.

Aims

To identify relevant deregulated proteins (DEP) in the secretome of a rat endotoxemic shock model.

Methods

Endotoxemic shock was induced in rats by intravenous injection of lipopolysaccharides (LPS, S. enterica typhi<

SUBMITTER: Blangy-Letheule A 

PROVIDER: S-EPMC8328724 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature