Expression profiles of human endogenous retrovirus (HERV)-K and HERV-R Env proteins in various cancers.

ABSTRACT: The vertebrate genome contains an endogenous retrovirus that has been inherited from the past millions of years. Although approximately 8% of human chromosomal DNA consists of sequences derived from human endogenous retrovirus (HERV) fragments, most of the HERVs are currently inactive and noninfectious due to recombination, deletions, and mutations after insertion into the host genome. Several studies suggested that Human endogenous retroviruses (HERVs) factors are significantly related to certain cancers. However, only limited studies have been conducted to analyze the expression of HERV derived elements at protein levels in certain cancers. Herein, we analyzed the expression profiles of HERV-K envelope (Env) and HERV-R Env proteins in eleven different kinds of cancer tissues. Furthermore

SUBMITTER: Ko EJ 

PROVIDER: S-EPMC8328825 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature