Reduced neural differentiation of rewards and punishment during passive avoidance learning in adolescents with generalized anxiety disorder.

ABSTRACT:

Background

It has been proposed that individuals with generalized anxiety disorder (GAD) show dysfunctional computations related to approach-avoidance decision-making. However, few studies have examined the neural basis of this impairment, particularly in adolescents with GAD. The goal of the current study was to address this gap in the literature.

Method

The study involved 51 adolescents with GAD and 51 typically developing (TD) comparison individuals matched on age (16.10 and 15.75 respective means), gender (30 F/21 M and 24 F/27 M), and IQ (103.20 and 103.18 respective means). Participants underwent functional magnetic resonance imaging during a passive avoidance task.

Results

We found a significant Group-by-Reinforcement interaction within reward-related brain reg

SUBMITTER: Bashford-Largo J 

PROVIDER: S-EPMC8328882 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature