Development and Validation of Test for "Leaky Gut" Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults.

ABSTRACT:

Background

Oral monosaccharides and disaccharides are used to measure in vivo human gut permeability through urinary excretion.

Aims

The aims were as follows: (1) to obtain normative data on small intestinal and colonic permeability; (2) to assess variance on standard 16 g fiber diet performed twice; (3) to determine whether dietary fiber influences gut permeability measurements; and (4) to present pilot data using 2 selected probes in patients with diarrhea-predominant irritable bowel syndrome (IBS-D).

Methods

Sixty healthy female and male adults, age 18-70 years, participated in 3 randomized studies (2 studies on 16.25 g and 1 study on 32.5 g fiber) in otherwise standardized diets. At each test, the following sugars were ingested: ¹²C-mannitol, ¹³

SUBMITTER: Khoshbin K 

PROVIDER: S-EPMC8328885 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature