Glucocorticoids and Androgens Protect From Gastric Metaplasia by Suppressing Group 2 Innate Lymphoid Cell Activation.

ABSTRACT:

Background & aims

The immune compartment is critical for maintaining tissue homeostasis. A weak immune response increases susceptibility to infection, but immune hyperactivation causes tissue damage, and chronic inflammation may lead to cancer development. In the stomach, inflammation damages the gastric glands and drives the development of potentially preneoplastic metaplasia. Glucocorticoids are potent anti-inflammatory steroid hormones that are required to suppress gastric inflammation and metaplasia. However, these hormones function differently in males and females. Here, we investigate the impact of sex on the regulation of gastric inflammation.

Methods

Endogenous glucocorticoids and male sex hormones were removed from mice using adrenalectomy and castration, respective

SUBMITTER: Busada JT 

PROVIDER: S-EPMC8328958 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature