Metabolomics-based discrimination of patients with remitted depression from healthy controls using ¹H-NMR spectroscopy.

ABSTRACT: The aim of the study was to investigate differences in metabolic profiles between patients with major depressive disorder (MDD) with full remission (FR) and healthy controls (HCs). A total of 119 age-matched MDD patients with FR (n = 47) and HCs (n = 72) were enrolled and randomly split into training and testing sets. A ¹H-nuclear magnetic resonance (NMR) spectroscopy-based metabolomics approach was used to identify differences in expressions of plasma metabolite biomarkers. Eight metabolites, including histidine, succinic acid, proline, acetic acid, creatine, glutamine, glycine, and pyruvic acid, were significantly differentially-expressed in the MDD patients with FR in comparison with the HCs. Metabolic pathway analysis revealed that pyruvate metabolism via the tricarboxylic a

SUBMITTER: Hung CI 

PROVIDER: S-EPMC8329159 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature