Pan-cancer association of HLA gene expression with cancer prognosis and immunotherapy efficacy.

ABSTRACT:

Background

The function of major histocompatibility complex (MHC) molecules is to bind peptide fragments derived from genomic mutations or pathogens and display them on the cell surface for recognition by cognate T cells to initiate an immune response.

Methods

In this study, we provide a comprehensive investigation of HLA gene expression in a pan-cancer manner involving 33 cancer types. We utilised gene expression data from several databases and immune checkpoint blockade-treated patient cohorts.

Results

We show that MHC expression varies strongly among cancer types and is associated with several genomic and immunological features. While immune cell infiltration was generally higher in tumours with higher HLA gene expression, CD4+ T cells showed significantly differen

SUBMITTER: Schaafsma E 

PROVIDER: S-EPMC8329209 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature