Ontology highlight
ABSTRACT:
SUBMITTER: Cui W
PROVIDER: S-EPMC8329287 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Cui Weiwei W Liu Dong D Gu Wei W Chu Bo B
Cell death and differentiation 20210317 8
It is well established that ferroptosis is primarily induced by peroxidation of long-chain poly-unsaturated fatty acid (PUFA) through nonenzymatic oxidation by free radicals or enzymatic stimulation of lipoxygenase. Although there is emerging evidence that long-chain saturated fatty acid (SFA) might be implicated in ferroptosis, it remains unclear whether and how SFA participates in the process of ferroptosis. Using endogenous metabolites and genome-wide CRISPR screening, we have identified FAR1 ...[more]